HUGIn

https://yunliweb.its.unc.edu/HUGIn/#plots

Methods

linear single view single scale single focus segregated no abstraction no arrangement between interconnection segment sparse type segment contiguous type point sparse type point contiguous type

Tool

Access Format: web application Supported Files: notapplicable License: unavailable

Paper

HUGIn: Hi-C Unifying Genomic Interrogator.

Martin JS, Xu Z, Reiner AP, Mohlke KL, Sullivan P, Ren B, et al. HUGIn: Hi-C Unifying Genomic Interrogator. Bioinformatics. academic.oup.com; 2017;33: 3793–3795.

Cited by: 31

Abstract

MOTIVATION: High throughput chromatin conformation capture (3C) technologies, such as Hi-C and ChIA-PET, have the potential to elucidate the functional roles of non-coding variants. However, most of published genome-wide unbiased chromatin organization studies have used cultured cell lines, limiting their generalizability. RESULTS: We developed a web browser, HUGIn, to visualize Hi-C data generated from 21 human primary tissues and cell lines. HUGIn enables assessment of chromatin contacts both constitutive across and specific to tissue(s) and/or cell line(s) at any genomic loci, including GWAS SNPs, eQTLs and cis-regulatory elements, facilitating the understanding of both GWAS and eQTL results and functional genomics data. AVAILABILITY AND IMPLEMENTATION: HUGIn is available at http://yunliweb.its.unc.edu/HUGIn.